The effect of bromocriptine-rebound method on ongoing pregnancy and live birth after intracytoplasmic sperm injection cycles: a randomized clinical trial

AUTHORS

Ashraf Alleyassin 1 , Ramak Esmailizad 2 , Marzieh Agha-Hosseini 1 , Leila Safdarian 1 , Fatemeh Sarvi 1 , * , Abas Kokab 2

1 Department of Infertility, Tehran University of Medical Sciences, Tehran, Iran, Andorra

2 Department of Infertility, Tehran University of Medical Sciences, Tehran, Iran., Andorra

How to Cite: Alleyassin A , Esmailizad R, Agha-Hosseini M , Safdarian L , Sarvi F , et al. The effect of bromocriptine-rebound method on ongoing pregnancy and live birth after intracytoplasmic sperm injection cycles: a randomized clinical trial, Ann Mil Health Sci Res. 2014 ; 12(3):e63508.

ARTICLE INFORMATION

Annals of Military and Health Sciences Research: 12 (3); e63508
Published Online: October 29, 2014
Article Type: Original Article
Received: June 17, 2014
Accepted: August 28, 2014

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Abstract

Materials and Methods: A total of 114 women underwent ICSI. Pregnancy outcomes and hormonal data were compared between two groups, i.e. long protocol and BRM. Ovulatory women with normal serum prolactin levels were assigned to either BRM (n = 57 cycles) or  long protocol (n = 57 cycles). Both procedures were carried out in a similar way. However, a group of patients were given bromocriptine daily from the 4th day of the preceding cycle until      7 days before gonadotropin   stimulation.

Results: There were no significant differences in the numbers of developed follicles,total retrieval oocytes, transferredembryo and embryos with superior morphology between the two groups. Also, the values of chemical, clinical and ongoing pregnancies and live births were not significantly different (36.8%, 35.1%, 28.1%, 28.1% in BRM group and 43.9%, 38.6%, 21.1% and 19.3%      in long protocol, respectively). Ongoing pregnancy and live birth were significantly higher in chemical pregnancy in the BRM group (P = .04 and P = .035, respectively).

Conclusion: This prospective study demonstrated that BRM might lead to higher ongoing pregnancy and live birth rates compared to the long protocol in women undergoing intracytoplasmic sperm  injection cycles.

Keywords

bromocriptine intracytoplasmic sperm injection live birth prolactin Iran

© 2014, Annals of Military and Health Sciences Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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