The most sensitive double-marker method of cardiac isoenzymes of creatinine kinase, troponin I, and myoglobin in different time periods for diagnosing acute myocardial infarction

AUTHORS

Kiumars Ahmadi 1 , Fahimeh Dadgari 1 , Mohammad Reza Safarinejadi Aghdam 2 , *

1 Department of Biochemistry, Bessat General Hospital, Aja University of Medical Sciences, Tehran, Iran, Andorra

2 Private Practice of Urology and Andrology, Tehran, Iran, Andorra

How to Cite: Ahmadi K , Dadgari F , Safarinejadi Aghdam M R. The most sensitive double-marker method of cardiac isoenzymes of creatinine kinase, troponin I, and myoglobin in different time periods for diagnosing acute myocardial infarction, Ann Mil Health Sci Res. 2014 ; 12(1):e63561.

ARTICLE INFORMATION

Annals of Military and Health Sciences Research: 12 (1); e63561
Published Online: January 22, 2014
Article Type: Original Article
Received: June 12, 2013
Accepted: December 10, 2013

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Abstract

Materials and Methods: This was an observational-analytic research on a diagnostic test conducted on 256 patients who had referred to the emergency department with chest pain from    4 to 24 hours before their referral. They were sorted equally into two groups of 4-14 hours and 15-24 hours from onset of pain, each group including 128 patients.

Results: In the first time period, the combination of troponin and myoglobin had the highest sensitivity (sensitivity = 97.3%, specificity = 98.1%), whereas the combination of double-marker and troponin proved the most sensitive (sensitivity = 100%, specificity = 96.3%).

Conclusion: The double-marker combination of troponin and myoglobin is more appropriate    for the first time period (i.e. during the first 24 hours from the onset of chest pain),while it would be more helpful to use the combination of troponin during the second period of time.

Keywords

myocardial infarction isoenzyme of creatinine kinase troponin myoglobin diagnosis

© 2014, Annals of Military and Health Sciences Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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