Effect of surgery stress and immobilization stress on ghrelin hormone level, body weight and food intake in female rats

AUTHORS

Zohre Genabzadeh Jahromy 1 , Parvin Zareian 2 , * , Habiboalah Johary 3 , Hosein Kargar Jahromy 4

1 Researcher, Biology Department, Jahrom Azad University, Jahrom, Iran, Andorra

2 Associate Professor, Physiology Department, AJA University of Medical Sciences, Tehran, Iran, Iran

3 Assistant Professor, Biology Department, Darab Azad University, Darab, Iran, Andorra

4 Instructor, Biology Department, Jahrom Azad University, Jahrom, Iran, Andorra

How to Cite: Genabzadeh Jahromy Z, Zareian P, Johary H, Kargar Jahromy H. Effect of surgery stress and immobilization stress on ghrelin hormone level, body weight and food intake in female rats, Ann Mil Health Sci Res. 2013 ; 11(1):e66742.

ARTICLE INFORMATION

Annals of Military and Health Sciences Research: 11 (1); e66742
Published Online: March 14, 2013
Article Type: Original Article
Received: November 28, 2012
Accepted: February 14, 2013

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Abstract

Background: Animal models of stress are a good for studying the stress induced disorders. The present study investigated the effect of immobilization and surgery stress on plasma ghrelin concentration, food intake and body weight.

Materials and Methods: This was an experimental study. 40 adult female rats were divided into 4 groups. Control group: no stress. In sham Group anesthetic and antibiotic drugs were administered. Surgery group rats were subjected surgery stress. Immobilization group rats were subjected to immobilization stress for 7 days. On the seventh day, blood samples were obtained directly from the animal’s heart. Serum Ghrelin concentrations were measured by ELISA. The changes in body weight during 7 days were recorded. Food intake was measured daily.

Results: Surgical stress had no significant effect on serum ghrelin concentrations but immobilization stress caused a significant increase in blood levels of ghrelin. Surgery and immobilization stress had no significant effect on body weight. Immobilization stress caused a significant increase in food intake.

Conclusion: The effect of Stress on serum ghrelin level and food intake depends on the kind of stress.

Keywords

Ghrelin Immobilization Stress Psychological Surgical Procedures Operative Body Weight Food Intake

© 2013, Annals of Military and Health Sciences Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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