Annals of Military and Health Sciences Research

Published by: Kowsar

Effect of Probiotic Supplementation on Oxidative Stress Enzymes and Mental Health of Athletes

Mahtab Noorifard 1 , Arasb Dabbagh Moghaddam 2 , Zatollah Asemi 3 , Ramin Hamidi Farahani 4 , Seyed Milad Mousavi Jazayeri 5 and Elahe Ebrahimi 5 , *
Authors Information
1 Department of Infectious Disease, Infectious Disease Research Center, AJA University of Medical Sciences, Tehran, Iran
2 Department of Public Health, Community Medicine and Infectiuos Disease Research center, Faculty of Medicine, AJA University Medical Sciences, Tehran, Iran
3 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
4 Department of Infectiuos Disease, Faculty of Medicine, AJA University of Medical Sciences,Tehran, Iran
5 Department of Microbiology, Infectious Disease Research Center, AJA University of Medical Sciences, Tehran, Iran
Article information
  • Annals of Military and Health Sciences Research: 17 (1); e84922
  • Published Online: January 20, 2019
  • Article Type: Research Article
  • Received: October 3, 2018
  • Revised: December 16, 2018
  • Accepted: December 18, 2018
  • DOI: 10.5812/amh.84922

To Cite: Noorifard M, Dabbagh Moghaddam A, Asemi Z, Hamidi Farahani R, Mousavi Jazayeri S M, et al. Effect of Probiotic Supplementation on Oxidative Stress Enzymes and Mental Health of Athletes, Ann Mil Health Sci Res. Online ahead of Print ; 17(1):e84922. doi: 10.5812/amh.84922.

Copyright © 2019, Annals of Military and Health Sciences Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Clark A, Mach N. Exercise-induced stress behavior, gut-microbiota-brain axis and diet: A systematic review for athletes. J Int Soc Sports Nutr. 2016;13:43. doi: 10.1186/s12970-016-0155-6. [PubMed: 27924137]. [PubMed Central: PMC5121944].
  • 2. Ramazaninezhad R. Study of the stressful factors of athletes of selected national teams of Iran. J Manage Exerc Dev. 2017;5(2):127-45.
  • 3. Mach N, Fuster-Botella D. Endurance exercise and gut microbiota: A review. J Sport Health Sci. 2017;6(2):179-97. doi: 10.1016/j.jshs.2016.05.001. [PubMed: 30356594]. [PubMed Central: PMC6188999].
  • 4. Negahdar M. Evaluation of the activity of superoxide disodotus glutathione peroxidase enzymes, erythrocyte catalase in smokers and non-smokers working in Kurdistan University of Medical Sciences. J Kurdistan Med. 2008;12:1-7.
  • 5. Martarelli D, Verdenelli MC, Scuri S, Cocchioni M, Silvi S, Cecchini C, et al. Effect of a probiotic intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training. Curr Microbiol. 2011;62(6):1689-96. doi: 10.1007/s00284-011-9915-3. [PubMed: 21400082].
  • 6. Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, et al. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry. 2001;58(5):445-52. [PubMed: 11343523].
  • 7. Zablocka A, Janusz M. [The two faces of reactive oxygen species]. Postepy Hig Med Dosw (Online). 2008;62:118-24. Polish. [PubMed: 18388851].
  • 8. Sies H, Stahl W. Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. Am J Clin Nutr. 1995;62(6 Suppl):1315S-21S. doi: 10.1093/ajcn/62.6.1315S. [PubMed: 7495226].
  • 9. Zhang X, Tao N, Wang X, Chen F, Wang M. The colorants, antioxidants, and toxicants from nonenzymatic browning reactions and the impacts of dietary polyphenols on their thermal formation. Food Funct. 2015;6(2):345-55. doi: 10.1039/c4fo00996g. [PubMed: 25468403].
  • 10. Asemi Z, Jazayeri S, Najafi M, Samimi M, Mofid V, Shidfar F, et al. Effect of daily consumption of probiotic yogurt on oxidative stress in pregnant women: A randomized controlled clinical trial. Ann Nutr Metab. 2012;60(1):62-8. doi: 10.1159/000335468. [PubMed: 22338626].
  • 11. Ulrich-Lai YM, Herman JP. Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci. 2009;10(6):397-409. doi: 10.1038/nrn2647. [PubMed: 19469025]. [PubMed Central: PMC4240627].
  • 12. Martins AS, Crescenzi A, Stern JE, Bordin S, Michelini LC. Hypertension and exercise training differentially affect oxytocin and oxytocin receptor expression in the brain. Hypertension. 2005;46(4):1004-9. doi: 10.1161/01.HYP.0000175812.03322.59. [PubMed: 16157794].
  • 13. Purvis D, Gonsalves S, Deuster PA. Physiological and psychological fatigue in extreme conditions: Overtraining and elite athletes. PM R. 2010;2(5):442-50. doi: 10.1016/j.pmrj.2010.03.025. [PubMed: 20656626].
  • 14. L'Abbé MR, Fischer PWF. Automated assay of superoxide dismutase in blood. In: Packer L, Glazer AN, editors. Methods in enzymology. 186. Elsevier; 1990. p. 232-7. doi: 10.1016/0076-6879(90)86113-A.
  • 15. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70(1):158-69. [PubMed: 6066618].
  • 16. Zarban A. Investigation of pattern of changes in antioxidant capacity in breastfeeding during the first six months of breastfeeding. J Iran Child Dis. 2007;17(1):34-40.
  • 17. Morfeld M, Petersen C, Kruger-Bodeker A, von Mackensen S, Bullinger M. The assessment of mood at workplace-psychometric analyses of the revised profile of mood states (POMS) questionnaire. Psychosoc Med. 2007;4:Doc06. [PubMed: 19742299]. [PubMed Central: PMC2736534].
  • 18. Pyne DB, West NP, Cox AJ, Cripps AW. Probiotics supplementation for athletes-clinical and physiological effects. Eur J Sport Sci. 2015;15(1):63-72. doi: 10.1080/17461391.2014.971879. [PubMed: 25339255].
  • 19. Mishra V, Shah C, Mokashe N, Chavan R, Yadav H, Prajapati J. Probiotics as potential antioxidants: A systematic review. J Agric Food Chem. 2015;63(14):3615-26. doi: 10.1021/jf506326t. [PubMed: 25808285].
  • 20. Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau JT, et al. Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: A pilot study in patients with irritable bowel syndrome. Gastroenterology. 2017;153(2):448-459. e8. doi: 10.1053/j.gastro.2017.05.003. [PubMed: 28483500].
  • 21. Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M, Jafari P, Akbari H, Taghizadeh M, et al. Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. Nutrition. 2016;32(3):315-20. doi: 10.1016/j.nut.2015.09.003. [PubMed: 26706022].
  • 22. Arseneault-Breard J, Rondeau I, Gilbert K, Girard SA, Tompkins TA, Godbout R, et al. Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model. Br J Nutr. 2012;107(12):1793-9. doi: 10.1017/S0007114511005137. [PubMed: 21933458].
  • 23. Ohland CL, Kish L, Bell H, Thiesen A, Hotte N, Pankiv E, et al. Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome. Psychoneuroendocrinology. 2013;38(9):1738-47. doi: 10.1016/j.psyneuen.2013.02.008. [PubMed: 23566632].
  • 24. Huang R, Ning H, Yang L, Jia C, Yang F, Xu G, et al. Efficacy of probiotics on anxiety: A meta-analysis of randomized controlled trials. Neuropsychiatry. 2017;7(6):862-71.
  • 25. Wang T, Hu X, Liang S, Li W, Wu X, Wang L, et al. Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats. Benef Microbes. 2015;6(5):707-17. doi: 10.3920/BM2014.0177. [PubMed: 25869281].
  • 26. Messaoudi M, Violle N, Bisson JF, Desor D, Javelot H, Rougeot C. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes. 2011;2(4):256-61. doi: 10.4161/gmic.2.4.16108. [PubMed: 21983070].
  • 27. Wang Y, Wu Y, Wang Y, Xu H, Mei X, Yu D, et al. Antioxidant properties of probiotic bacteria. Nutrients. 2017;9(5). doi: 10.3390/nu9050521. [PubMed: 28534820]. [PubMed Central: PMC5452251].

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