Brain-derived neurotrophic factor, insulin-like growth factor 1 and its binding protein responses to a session of endurance exercises in healthy elderly men

AUTHORS

Fariborz Hovanloo 1 , mohsen shabani 2 , * , Khosro Ebrahim 3 , Mehdi Hedayati 4

1 Department of Physical Education and Sports Science, Shahid Beheshti University, Tehran, Iran., Andorra

2 Department of Physical Education and Sports Science, Shahid Beheshti University, Tehran, Iran, Andorra

3 Department of Physical Education and Sports Science, Shahid Beheshti University, Tehran, Iran., Andorra

4 Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Andorra

How to Cite: Hovanloo F , shabani M, Ebrahim K , Hedayati M . Brain-derived neurotrophic factor, insulin-like growth factor 1 and its binding protein responses to a session of endurance exercises in healthy elderly men, Ann Mil Health Sci Res. 2014 ; 12(1):e63523.

ARTICLE INFORMATION

Annals of Military and Health Sciences Research: 12 (1); e63523
Published Online: February 18, 2014
Article Type: Original Article
Received: October 16, 2013
Accepted: December 19, 2013

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Abstract

Materials and Methods: Eleven healthy old males (mean age of 68 ± 2.31 years old, height      of 177 ± 3.1 cm and weight of 79 ± 1.5 kg) were studied. Seventy two hours after maximal oxygen consumption (VO2 max) evaluation, the participants performed an endurance activity at the intensity of 70% of their VO2 max. Three blood samples were collected from the antecubital vein before, immediately and 30 minutes after the activity. The data were analyzed by repeated measures (P     .05).

Results: There was a significant increase in serum BDNF and IGF-1 immediately after the endurance activity (P = .040 and P = .047, respectively). However, 30 minutes after the activity, there were no significant changes in serum BDNF and IGF-1 compared to the serums before the activity. There was also no significant change in IGFBP-3 immediately and 30 minutes after the research protocol relative to serums before activity (P = .067 and P = .154, respectively).

Conclusion: The findings showed that BDNF and IGF-1 increase significantly in response to endurance activity, but no significant change was observed in IGFBP-3. Endurance activities might contribute to an increase in neurotrophical factors involved in memory and cognitive function which in turn decrease the incidence of neurological diseases such as Alzheimer, depression and many other related neurophysiological ones in elderly adults

Keywords

brain-derived neurotrophic factor (BDNF insulin-like growth factor 1 (IGF-1 insulin-like growth factor binding protein 3 (IGFBP-3) endurance exercise elderly men

© 2014, Annals of Military and Health Sciences Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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