Chlamydia pneumoniae infection in patients with atherosclerotic plaques

AUTHORS

Farhad Lahmi 1 , Mohammad Rostami Nejad 2 , Ehsan Nazemalhosseini Mojarad 3 , Hossein Godarzi 4 , Hossein Ahmadi 5 , Hossein Dabiri 6 , *

1 Assistant Professor, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Andorra

2 - Researcher, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Andorra

3 Researcher, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Andorra

4 - Professor, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Andorra

5 Assistant Professor, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Andorra

6 Assistant Professor, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Andorra

How to Cite: Lahmi F, Rostami Nejad M , Nazemalhosseini Mojarad E , Godarzi H , Ahmadi H , et al. Chlamydia pneumoniae infection in patients with atherosclerotic plaques, Ann Mil Health Sci Res. 2013 ; 11(3):e65052.

ARTICLE INFORMATION

Annals of Military and Health Sciences Research: 11 (3); e65052
Published Online: September 24, 2013
Article Type: Original Article
Received: April 21, 2013
Accepted: August 24, 2013

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Previous studies showed that microbial infection such as Chlamydia pneumoniae is contributed to the development of atherosclerosis. This study evaluated the prevalence of C. pneumoniae in atherosclerotic plaques by PCR and immunofluorescence assay (IFA), and also it examined the correlation of disease severity and the presence of this bacterium. Materials and Methods: In this descriptive study sixty four specimens, thirty three plaques in case group and thirty one plaques in control group were assessed in Tehran University of Medical Sciences affiliated hospitals. The plaques was assessed by PCR nor IFA method. The data was analyzed by SPSS and t-test and fisher exact test was used. Results: Out of 33 case specimens, C. pneumoniae DNA and antigen were found in 6 (18%) and 7 (21%) of endarterectomy specimens, respectively. While none of control specimens was positive for C. pneumoniae either by neither PCR nor IFA method. Conclusion: Respect to remarkable presence of C. pneumoniae in atherosclerotic tissues and its absence in healthy vessels supports the hypothesis that C. pneumoniae may play an important role in the development of atherosclerosis, especially in regions where infection is frequent but the exact mechanisms for high prevalence of atherosclerotic vascular disease are not fully understood.

Keywords

Chlamydophila pneumonia Plaque Atherosclerotic Polymerase Chain Reaction Fluorescent Antibody Technique

© 2013, Annals of Military and Health Sciences Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

Full text is available in pdf

References

  • 1.

    References are available in pdf

  • COMMENTS

    LEAVE A COMMENT HERE: